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Chondrosarcoma is a malignant tumor of cartilage-producing cells, characterized by the formation of neoplastic hyaline cartilage.

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• It is the second most common primary malignant bone tumor (after Osteosarcoma ), and typically affects adults over the age of 40.

Classification

2020 WHO Classification: https://doi.org/10.3390/cancers15061703

![Schematic representation of conventional cartilaginous tumors of bone. The figure represents the benign bone lesions, osteochondromas (sessile osteochondroma and pedunculated osteochondroma), chondromas (enchondroma and periosteal chondroma), their location, and the frequency of somatic tumors present in these lesions (left part). These lesions may progress to malignant conventional chondrosarcomas (middle part). To note, conventional chondrosarcomas may be primary or secondary tumors. In some cases, central and peripheral conventional chondrosarcomas may progress to dedifferentiated chondrosarcomas (right part).

Tlemsani C, Larousserie F, De Percin S, Audard V, Hadjadj D, Chen J, Biau D, Anract P, Terris B, Goldwasser F, et al. Biology and Management of High-Grade Chondrosarcoma: An Update on Targets and Treatment Options. International Journal of Molecular Sciences. 2023; 24(2):1361. https://doi.org/10.3390/ijms24021361](attachment:ccf8b26a-7937-4660-91ad-fdb00cdbeb08:ijms-24-01361-g001.webp)

Schematic representation of conventional cartilaginous tumors of bone. The figure represents the benign bone lesions, osteochondromas (sessile osteochondroma and pedunculated osteochondroma), chondromas (enchondroma and periosteal chondroma), their location, and the frequency of somatic tumors present in these lesions (left part). These lesions may progress to malignant conventional chondrosarcomas (middle part). To note, conventional chondrosarcomas may be primary or secondary tumors. In some cases, central and peripheral conventional chondrosarcomas may progress to dedifferentiated chondrosarcomas (right part).

Tlemsani C, Larousserie F, De Percin S, Audard V, Hadjadj D, Chen J, Biau D, Anract P, Terris B, Goldwasser F, et al. Biology and Management of High-Grade Chondrosarcoma: An Update on Targets and Treatment Options. International Journal of Molecular Sciences. 2023; 24(2):1361. https://doi.org/10.3390/ijms24021361

Clinical Features

Epidemiology:

• Deep, dull, and progressive pain
• Palpable mass (especially in flat bones like pelvis)
• Neurological symptoms if spine involved
• Often slow-growing, but may become aggressive over time

Common locations:

Secondary Chondrosarcoma