<aside>

Idiopathic Pulmonary Fibrosis (IPF) is the most common and most aggressive form of idiopathic interstitial pneumonia (IIP), defined by progressive pulmonary fibrosis of unknown cause, occurring primarily in older adults, with a characteristic Usual interstitial pneumonia (UIP) pattern on imaging and/or histopathology.

</aside>

https://www.youtube.com/watch?v=UlIXdyW03Os&t=594s

https://youtu.be/qjDNp54o_bI

https://www.youtube.com/watch?v=ZRSZ-rHVWFg

Epidemiology

https://www.youtube.com/watch?v=VzuXGu2z0ro

Feature	Details
Age	>60 years (rare <50 years)
Sex	Male > Female
Smoking	Major risk factor
Environmental/occupational exposure	Metal dust, farming, wood dust
Genetic predisposition	TERT, TERC, surfactant protein mutations
GERD	Strongly associated comorbidity

Pathology

https://doi.org/10.1007/s00018-020-03693-7

https://doi.org/10.3390/biology12091237

https://doi.org/10.3389/fmed.2018.00010

Pathophysiology

Progressive fibrosing interstitial lung disease driven by abnormal wound healing in response to alveolar epithelial injury.
Results in fibroblastic foci, collagen deposition, and honeycomb lung.
No significant inflammation (in contrast to NSIP or HP).

Epidemiology

Pathology

Pathophysiology

Histopathology