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Kartagener syndrome is a rare congenital disorder characterized by the triad of:

  1. Situs inversus totalis
  2. Chronic sinusitis
  3. Bronchiectasis </aside>

https://www.youtube.com/watch?v=rNbWSLBSGL8

It is a subset of Primary ciliary dyskinesia (PCD)—a disorder of abnormal motile ciliary function, leading to ineffective mucociliary clearance throughout the respiratory tract and related systems.

Etiopathogenesis

Pathophysiology:

The role of epithelial ciliary movement in airway clearance. Packi K, Fugiel W, Gołąbek V, Rudek A, Śliwińska A. Eosinophilic Pneumonia Triggered by Toxocara canis in a Patient with Primary Ciliary Dyskinesia: A Clinical Case Report. Medicina. 2024; 60(11):1874. https://doi.org/10.3390/medicina60111874

The role of epithelial ciliary movement in airway clearance. Packi K, Fugiel W, Gołąbek V, Rudek A, Śliwińska A. Eosinophilic Pneumonia Triggered by Toxocara canis in a Patient with Primary Ciliary Dyskinesia: A Clinical Case Report. Medicina. 2024; 60(11):1874. https://doi.org/10.3390/medicina60111874

Clinical Features

System Manifestations
Respiratory Chronic productive cough, bronchiectasis, recurrent pneumonia
ENT Chronic rhinosinusitis, nasal polyps, otitis media
Cardiovascular Situs inversus totalis (heart on right)
Reproductive Infertility in males (immotile sperm); subfertility in females
Neonatal Respiratory distress in term infants (due to mucus plugging)

Etiology and complications of Kartagener’s syndrome. Packi K, Fugiel W, Gołąbek V, Rudek A, Śliwińska A. Eosinophilic Pneumonia Triggered by Toxocara canis in a Patient with Primary Ciliary Dyskinesia: A Clinical Case Report. Medicina. 2024; 60(11):1874. https://doi.org/10.3390/medicina60111874

Etiology and complications of Kartagener’s syndrome. Packi K, Fugiel W, Gołąbek V, Rudek A, Śliwińska A. Eosinophilic Pneumonia Triggered by Toxocara canis in a Patient with Primary Ciliary Dyskinesia: A Clinical Case Report. Medicina. 2024; 60(11):1874. https://doi.org/10.3390/medicina60111874

Complications