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Methanol intoxication appears after accidental or suicidal oral ingestion of industrial solvents or cleaning and antifreeze liquids or occasionally is due to fraudulent adulteration of wine or other alcoholic beverages. Its ingestion can cause severe metabolic acidosis and clinical disturbances such as blindness, permanent neurologic dysfunction, and death.
https://www.ajnr.org/content/27/2/452/tab-article-info
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. Oxidation of methanol to formaldehyde by alcohol dehydrogenase is the rate limiting step in the metabolism of methanol that is inhibited by fomepizole. Administration of folic acid enhances catabolism of formic acid to carbon dioxide and water by 10-tetrahydrofolate synthetase.
Radiología en 5 minutos: Intoxicación por metanol
https://pubmed.ncbi.nlm.nih.gov/16484428/
https://doi.org/10.5144/0256-4947.2012.26.5.1114
Most common findings:
MRI shows bilateral hemorrhagic necrosis of the putamen and globus pallidus as shown by mixed isointense and hypointense areas on the T2-weighted image (a), hyperintensity on the T1-weighted image (b), and strong enhancement on the contrast-enhanced image (c)
Sefidbakht, S., Rasekhi, A.R., Kamali, K. et al. Methanol poisoning: acute MR and CT findings in nine patients. Neuroradiology 49, 427–435 (2007). https://doi.org/10.1007/s00234-007-0210-8
Bilateral lentiform nucleus necrosis (predominantly putamen) (A-C), and scattered hemorrhages (D). Subcortical white matter lesions in the frontal and occipital regions; involvement of the hippocampus (E, F).
Hoang TN, Le V, Thien TC, The HT, Tri DP, Van PL. Characteristics of brain magnetic resonance imaging in acute methanol intoxication: Report of 3 cases. Radiology Case Reports. 2023;18(12):4414-4418. doi:https://doi.org/10.1016/j.radcr.2023.09.019
Case reports:
https://doi.org/10.1111/j.1440-1673.2007.01691.x
https://doi.org/10.1007/s00234-007-0210-8
https://neurologyopen.bmj.com/content/4/1/e000221