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Sjögren syndrome is a chronic, systemic autoimmune disorder primarily characterized by lymphocytic infiltration and destruction of exocrine glands, especially the salivary and lacrimal glands, leading to xerostomia (dry mouth) and keratoconjunctivitis sicca (dry eyes).

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Sjogren syndrome: Pathology review

https://www.youtube.com/watch?v=FAspQVAJUto

https://www.youtube.com/watch?v=hB8u1zBd4VI

Scientific history:

Milestones in the history of SjS compressed in 100 years (1882–1982): Patients affected by isolated sicca symptoms were first reported at the end of the nineteenth century and symptoms were integrated into a ‘sicca syndrome’ by Gougerot in 1925. However, the first to suggest they could be attributed to a systemic disease was the Swedish ophthalmologist Henrik Sjögren, who, in 1933, established that the disease spectrum extended beyond glandular involvement. Subsequent studies in the mid-twentieth century confirmed the association of sicca syndrome with other rheumatic and autoimmune diseases and with an unusually high frequency of haematological malignancies. The autoimmune aetiopathogenetic basis of Sjögren syndrome (SjS) was confirmed in the 1960s, and the presence of autoantibodies (Ro/SSA and La/SSB) and organ-specific lymphocytic infiltration (focal lymphocytic sialadenitis) become central for the pathobiology and diagnosis of the disease. Brito-Zerón, P., Baldini, C., Bootsma, H. et al. Sjögren syndrome. Nat Rev Dis Primers 2, 16047 (2016). https://doi.org/10.1038/nrdp.2016.47

Milestones in the history of SjS compressed in 100 years (1882–1982): Patients affected by isolated sicca symptoms were first reported at the end of the nineteenth century and symptoms were integrated into a ‘sicca syndrome’ by Gougerot in 1925. However, the first to suggest they could be attributed to a systemic disease was the Swedish ophthalmologist Henrik Sjögren, who, in 1933, established that the disease spectrum extended beyond glandular involvement. Subsequent studies in the mid-twentieth century confirmed the association of sicca syndrome with other rheumatic and autoimmune diseases and with an unusually high frequency of haematological malignancies. The autoimmune aetiopathogenetic basis of Sjögren syndrome (SjS) was confirmed in the 1960s, and the presence of autoantibodies (Ro/SSA and La/SSB) and organ-specific lymphocytic infiltration (focal lymphocytic sialadenitis) become central for the pathobiology and diagnosis of the disease. Brito-Zerón, P., Baldini, C., Bootsma, H. et al. Sjögren syndrome. Nat Rev Dis Primers 2, 16047 (2016). https://doi.org/10.1038/nrdp.2016.47

Epidemiology

Pathogenesis

Untitled

Clinical Features